The SHBG test measures the level of sex hormone-binding globulin, a protein that binds to testosterone and oestradiol in the bloodstream. SHBG levels influence the availability of these hormones for biological activity.

High SHBG levels in males and females may lead to symptoms of hormonal imbalances, such as decreased libido, menstrual irregularities, and symptoms of low testosterone or oestrogen.

Low SHBG levels in males and females may be associated with conditions like obesity, insulin resistance, or polycystic ovary syndrome (PCOS), leading to symptoms such as acne, excessive hair growth, and irregular menstrual cycles.